Sabril® (vigabatrin) for Refractory Complex Partial Seizures (CPS)

Patient taking Sabril for his refractory complex partial seizures.

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Sabril is a prescription medicine used along with other treatments in adults and children 10 years of age and older with refractory complex partial seizures (CPS) if:

  • The complex partial seizures do not respond well enough to several other treatments, and
  • You and your doctor decide the possible benefits of taking Sabril are more important than the risk of permanent vision loss

Sabril should not be the first medicine used to treat your CPS.

Possible Benefits of Sabril for Refractory CPS

In adults and children 10 years of age and older for whom the possible benefits of treatment outweigh the risks of permanent vision loss, Sabril can be used as an add-on therapy to help reduce the number of refractory CPS. The effectiveness of Sabril in adults was established in 2 clinical trials reviewed by the US Food and Drug Administration (FDA). For children 10 to 16 years of age with refractory CPS, researchers looked at 2 studies in adults and at data in children, which together were used to show effectiveness and determine proper dosing in this age group.

About Refractory CPS

A complex partial seizure (CPS) is a type of seizure that starts in a specific area of the brain and can affect consciousness. Typically, complex partial seizures last between 30 and 90 seconds, and are often followed by a period of disorientation, confusion and/or fatigue. Complex partial seizures may happen in either side of the brain.1

Symptoms of Complex Partial Seizures1

Complex partial seizures may cause you to:

Lose consciousness

Be unaware of what is happening during the seizure

Stare blankly

Move or act without purpose. You may chew, mumble, pick at the air, or act strangely. These are called automatisms

Feel confused or sleepy after the seizure

Refractory Complex Partial Seizures

Sometimes a person’s seizures cannot be controlled even after he or she has tried several antiepileptic medicines. When this happens, it is called refractory epilepsy.2 In a medical study of people with epilepsy, about 1 of 3 had refractory epilepsy.3 Why this happens and whether it can be predicted is unclear.

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References

  1. 1. Complex Partial Seizures. Epilepsy Foundation website. http://www.epilepsy.com/epilepsy/seizure_complexpartial. Accessed February 16, 2017.
  2. 2. Refractory Epilepsy. Epilepsy Foundation website. http://www.epilepsy.com/learn/refractory-epilepsy. Accessed February 16, 2017.
  3. 3. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342(5):314-319.

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