Taking Sabril® (vigabatrin)

For Refractory CPS Patients

Sabril is available in 500 mg tablets or as packets of 500 mg powder for oral solution. It is taken by mouth with or without food. Either tablet or powder can be used for adults and children 10 years of age or older with refractory CPS. Your doctor will tell you how much to take each day. Ask your doctor what you should do if a dose is missed. Be sure to tell your doctor if you or your child has any side effect that bothers you or that does not go away. Please read the Medication Guide that comes with the prescription before starting Sabril, and with each refill, as there may be new information.

[[purple]All people who take Sabril are at risk for permanent vision loss with any amount of Sabril.]

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About Taking Sabril

  • Sabril is available only from a certified pharmacy
  • Take Sabril exactly as your doctor tells you to. Sabril is usually taken 2 times each day
  • Before starting to take Sabril, talk to your healthcare provider about what you or your child should do if a Sabril dose is missed
  • Do not stop taking Sabril suddenly without talking to your doctor, as this can cause serious problems.
    Stopping Sabril or any seizure medicine suddenly can cause seizures that will not stop (status epilepticus) in people who are being treated for seizures
  • Sabril causes sleepiness and tiredness. Adults taking Sabril should not drive, operate machinery, or perform any hazardous task, unless you and your doctor have decided that you can do these things safely

Learn more about the risks of side effects with Sabril

Importance of Monitoring Your Response to Sabril

Because of the risk of permanent vision loss:

  • If you (or your child) don't experience a benefit from Sabril within the first 3 months, or if treatment failure becomes obvious sooner than 3 months, your doctor should slowly stop the medicine
  • Your (or your child's) response to and continued need for Sabril should be periodically checked by your doctor
  • It is recommended that your doctor test your (or your child’s) vision before or within 4 weeks after starting Sabril, and at least every 3 months during treatment until Sabril is stopped. It is also recommended that vision be tested about 3 to 6 months after Sabril is stopped

For Infantile Spasms Patients

Sabril comes in a powder form that you mix with water. Your baby will take Sabril by mouth. Your doctor will tell you how much medicine to give your baby. Talk with your doctor if you have any questions about the right dose of medicine to give your baby or how to mix it.

[[purple]All people who take Sabril are at risk for permanent vision loss with any amount of Sabril.]

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Learn more about the risks of side effects with Sabril

Important Information About Dosing

  • Each packet contains 500 mg of Sabril powder for oral solution

  • Sabril is usually given 2 times each day

  • Your baby’s doctor will tell you:

    • How many packets of Sabril your baby will need for each dose
    • How many milliliters (mLs) of water to use to mix a dose of Sabril for your baby
    • How many milliliters (mLs) of the mixture you will need to give your baby after the powder is mixed with water

  • Before your baby starts taking Sabril, speak to your baby’s doctor about what to do if your baby misses a dose, vomits, spits up, or only takes part of the dose of Sabril

  • Do not suddenly stop giving your baby Sabril, as this can cause serious problems, such as seizures that will not stop (status epilepticus)

Important Information About Mixing

  • Mix Sabril for oral solution and give it to your baby exactly as prescribed by your doctor
  • The powder in the packets must be mixed with water only
  • The water may be cold or at room temperature
  • Sabril can be given to your baby at the same time as his or her food, but the powder should not be mixed with the baby's food
  • Sabril oral solution should be given to your baby right away after it is mixed

Download step-by-step mixing instructions for Sabril

Importance of Monitoring Your Infant’s Response

Because of the risk of permanent vision loss:

  • If your baby does not show an improvement within 2 to 4 weeks or sooner, your doctor should slowly stop the medicine
  • Your baby's response to (and continued need for) Sabril should be periodically checked by your baby's doctor
  • Tell your doctor right away if you think your baby is not seeing as well as before taking Sabril, or is acting differently than normal

When Stopping Sabril

If your doctor tells you to stop your baby’s treatment, inform your doctor right away about any increase in spasms your baby has while you are stopping Sabril.

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